Symbol
Name
ID

Coro1a
coronin, actin binding protein 1A
MGI:1345961

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine	Complete or near-complete absence of specific antibody response to tetanus vaccine	Lymphopenia
Disease(s) Associated with CORO1A
coronin-1A deficiency

Mouse Phenotypes

increased T cell apoptosis

abnormal leukocyte migration

decreased T cell proliferation

increased mast cell degranulation

impaired macrophage phagocytosis

decreased thymocyte number

increased thymocyte number

abnormal thymocyte activation

enlarged spleen

increased spleen weight

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased memory T cell number

decreased T cell number

decreased monocyte cell number

abnormal effector T cell morphology

decreased spleen weight

abnormal T cell physiology

abnormal T cell activation

Availability

Mouse Genotype

Coro1a^koy/Coro1a^koy

Coro1a^{Lmb3-C57BL/6Scr}/Coro1a^{Lmb3-C57BL/6Scr}

Coro1a^{Lmb3-MRL/MpScr}/Coro1a^{Lmb3-MRL/MpScr}

Coro1a^ptcd/Coro1a^ptcd

Coro1a^tm1Achn/Coro1a^tm1Achn

Coro1a^tm1Jpie/Coro1a^tm1Jpie

Coro1a^ptcd/Coro1a^tm1Achn

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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